Effect of tetrabenazine on computerized dynamic posturography in Huntington disease patients
نویسندگان
چکیده
منابع مشابه
Effect of Tetrabenazine on Motor Function in Patients with Huntington Disease
INTRODUCTION Tetrabenazine (TBZ) reduces chorea related to Huntington disease (HD); however, it is uncertain whether this effect improves functionally relevant motor skills such as hand coordination and balance. The objective of this study was to provide pilot data regarding three motor function tests, which might be useful in monitoring symptom progression and therapeutic response, pending for...
متن کاملModified head shake computerized dynamic posturography.
PURPOSE Recent research on head shake posturography has demonstrated a modest increase in sensitivity to identifying peripheral vestibular system asymmetry when horizontal head movements were added to portions of the standard Sensory Organization Test (SOT) battery. However, limitations with respect to the head shake protocol were outlined, and usable data for assessing performance could not be...
متن کاملIndirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease
BACKGROUND Vesicular monoamine transporter 2 (VMAT2) inhibitors can improve hyperkinetic movements, and are effective treatment options for chorea of Huntington disease (HD). Tetrabenazine was assessed for treating chorea in the TETRA-HD trial, and while efficacious, there are tolerability concerns possibly due to its pharmacokinetic properties. Deutetrabenazine is a novel VMAT2 inhibitor that ...
متن کاملTetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease
Huntington disease (HD) is a dominantly inherited progressive neurological disease characterized by chorea, an involuntary brief movement that tends to flow between body regions. HD is typically diagnosed based on clinical findings in the setting of a family history and may be confirmed with genetic testing. Predictive testing is available to those at risk, but only experienced clinicians shoul...
متن کاملMisclassification of Patients with Spinocerebellar Ataxia as Having Psychogenic Postural Instability Based on Computerized Dynamic Posturography
Specific criteria have been developed based on computerized dynamic posturography (CDP) to assist clinicians in identifying patients with psychogenic balance problems (Cyr and Cevette, 1993; Cevette et al., 1995; Goebel et al., 1997; Gianoli et al., 2000). Patients with known spinocerebellar ataxia (SCA) meet several of the criteria for psychogenic balance problem and risk being misclassified a...
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ژورنال
عنوان ژورنال: Parkinsonism & Related Disorders
سال: 2012
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2012.04.029